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After reviewing the IMPROVE-IT results, Krumholz said the evidence now supports the use of ezetimibe, which he said may prove to be safer than statin therapy.
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Caucasians, 4% Asian, 2% Blacks, 13% multi-racial) with HeFH were randomized to receive either ezetimibe coadministered with simvastatin or simvastatin monotherapy.
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Five multicenter, double-blind studies conducted with either VYTORIN or coadministered ezetimibe and simvastatin equivalent to VYTORIN in patients with primary hyperlipidemia are reported: two were comparisons with simvastatin, two were comparisons with atorvastatin, and one was a comparison with rosuvastatin.
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Patients should be placed on a standard cholesterol-lowering diet before initiation of ezetimibe therapy and should remain on this diet during treatment with the drug.
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The FDA has for its cholesterol-lowering drug ezetimibe, either by itself (Zetia) or in combination with simvastatin (Vytorin).
