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Therefore, strategies to overcome EGFR TKI resistance remain practical needs in order to prolong survival time of patients with lung cancer.
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Signal transduction pathways and other functional groupings of genes were evaluated for differential regulation using the visualization tool GenMAPP (University of California at San Francisco).
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Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials.
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Postoperative (adjuvant) radiation therapy (PORT) was administered to 62 patients (40%) in the surgery arm.
Does not inhibit CYP isoenzymes 1A2, 2C9, or 3A4 in vitro, but may inhibit 2C19 and 2D6 at high drug concentrations.
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The purposes of the panel meeting were to refine the questions addressed by the guideline, solicit input and testimony from the nonwriting advisory panel, and make writing assignments for the respective sections.
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In 2006, its manufacturer announced that it would withdraw pending applications for marketing approval after reports of (liver damage) during trials, and discontinue its distribution in countries where the drug had been approved (Germany, Portugal, Sweden, Finland, Norway, Iceland, Austria, Denmark, France, Switzerland, Argentina and Brazil).
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Other side effects not listed may also occur in some patients.
Baseline factors found to be significant by univariate analysis were incorporated in logistic regression multivariate models to identify baseline factors that might independently predict response and disease control.
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Bernstein CN, Blanchard JF, Rawsthorne P: The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study.
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For patients with unknown EGFR status who are unfit for chemotherapy, the phase III TOPICAL study () found a significant survival benefit with first-line erlotinib over placebo but only in those who developed a rash within 28 days.
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On the other hand, it is interesting that 27% of our patients with glioblastoma did have a discernible aberration on ctDNA testing, suggesting the possibility that, as this technology improves and incorporates highly prevalent alterations such as EGFR vIII indels, it may become usable for even higher percentages of these patients.