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Among 46 additional abstracts related to the treatment of dystonia, only 2 were focused on oral medications: (1) a small study of dronabinol for cervical dystonia did not generate optimistic results and (2) the other abstract described positive effects of trihexyphenidyl on dystonic posturing in two girls with Rett syndrome.
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One of the most frustrating symptoms of advanced Parkinson's disease is longer periods of time spent when movement is poor, and is known as the "off state" or " off period.
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Overt signs of Parkinson's disease are associated with an 80%-plus loss of dopamine-producing neurons in the of the midbrain.
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First, if the production of free radicals, as the result of dopamine metabolism, contributes to the death of nigrostriatal neurons, the addition of levodopa can accelerate the process, although no convincing evidence for this effect has yet been obtained.
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Current evidence suggests that rasagiline may be more effective than selegiline in salvaging dopamine nerve cells from the usual neurological carnage of later life.
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Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.
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Identifying biomarkers (signs that may indicate risk of a disease and improve diagnosis) will speed the development of novel therapeutics for PD.
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Levodopa, also called L-dopa, which is converted to dopamine in the brain, remains the gold standard for treating Parkinson disease (PD) symptoms.
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